I've used these for years to help with my occasional long party nights. If I take 1-2 with my first drink, mix drinking plenty of water with my hard drinks, and have 1-2 more as I wind down and sleep, I wake the next day a little worn out but otherwise very functional. They do exactly what I want them to do.My only issue is that they spoil before I make it through a bottle. After maybe 9 months or so, they change appearance, getting spotty instead of the even brown-grey color. And they start to smell nasty and are hard to choke down. They are still useful enough to help until I pick up another bottle, but I hate that I never get more than 3/4 through a bottle before they go bad. So I'm going to try an find another brand with the same ingredients and a more stable formulation. I hope it works.